eIF4A3 inhibitor 53a

Research use only, not for human use.

eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM.

eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM; displays no activity against eIF4A1, eIF4A2, DHX29 and BRR2 ATPase (IC50>100 uM); binds to a non-ATP binding site of eIF4A3, exhibits cellular nonsense-mediated RNA decay (NMD) inhibitory activity and represents a novel molecular probe for further study of eIF4A3, the exon junction complex (EJC) and NMD.

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Nuclear Receptor/Transcription Factor

eIF

eIF

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2095486-67-0

588.89

C29H23BrClN5O2

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (339.63 mM)

ClC(C=C1)=CC=C1[C@@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2

3-(4-(((3S)-4-(4-Bromobenzoyl)-3-(4-chlorophenyl)-piperazin-1-yl)carbonyl)-5-methyl-1H-pyrazol-1-yl)-benzonitrile

(-20℃)

With Ice Pack

≥ 2 years